Oh PLEASE stay away from Fisherman's Wharf! Excellent seafood can be had at many places: My favorites: Bar Agricole, Contigo, Foreign Cinema, Boulevard. Contigo sources all seafood locally.... and is in a great neighborhood. Boulevard is classic San Francisco. I would NOT go to The Waterfront- overpriced and poorly executed food (touristy/business meeting type place). If I did stay by the bay, I'd go to Pier 23 for funky outdoor seafood or to the Ferry Building (Slanted Door).