As someone who lives downtown and frequents the nightlife here's a list for you:
-Thirsty lion (previously mentioned, good bar, kinda commercial) SW 2nd and Ash
-On Deck (its in the Pearl, good sports bar) NW Kearney between 12th and 13th
-Paddy's Bar and Grill (they have fewer tv's but they have the biggest alcohol assortment in Portland, excellent bartenders, good ambiance) SW 1st and Yamill
-Buffalo Wild Wings (meh! why did I put this on the list?) SW Morrison between 3rd and 4th
- Blitz Pearl (good bar, might be fratty that night) NW 10th and Couch
- Life of Riley Tavern (good food and drink, wider beer assortment) NW 10th and Everett
Good luck ladies and enjoy your time in Portland!