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Lunch stop on I 65

I65 is kind of a dull drive. It might be too close, but there is a nice place I like stopping at (usually coming back from Chicago) It's an hour to the north in West Lafayette. It's the middle of the three exits. Spagheddi's. It's a chain, but I do like the food and it's a nice break on the boring drive.

Downtown Indianapolis

For lunch there is a very good pub that's close to you. By your description, it should either be next door (on Washington St) or just around the corner. Loughmiller's Pub. You can check theri website at loughmillerspub dot com. There are of course plenty of chain restaurants. There are many chain restaurants and the Circle Center Mall has a food court with a Johnny Rocket's that's popular.
For dinner it's mostly chains again downtown. There are some nice options. If you like Mexican, Adobo Grill is on Washington near you and has very good guacamole made table side. Ask to sit in the lounge area by the window. You will overlook the street which gives a good view. Indy has a couple of Ruth's Chris steak houses and the one downtown is very nicely laid out. Near downtown (can be walked but it's kind of a hike is a wonderful local place. It's a bar, but the restaurant has excellent food. Ralph's Great Divide is on New York St. The home made desserts are the best. People who think they don't really like coconut cream pie will ask for seconds. There is a link on the Indianapolis Star website to a review. They are only open to the public Mon-Fri. A couple of blocks closer to downtown on New York is a local Italian restaurant called Amici's. Try the bruschetta, it's made with a mushroom pate. Also near downtown but again you'll want to drive is a terrific Greek restaurant, Santorini.
I hope you will get some time to explore the Indiana State Museum and/or the Eiteljorg Museum as well. Enjoy your stay.

Indianpolis Cheap Eats?

There are two versions of El Sol de Tala. The original is at 2444 East Washington. There's another one tucked away in Union Station right down town. Excellent Mexican food (really yummy guacamole) and both places are kid friendly. Cheerful colorful places to go.
For Italian go to Iaria's which is on South College Ave. Very good food (I prefer it over Milan Inn a couple of doors north) and also kid friendly.

Indianpolis Cheap Eats?

Not a burger joint exactly but great food at Ralph's Great Divide. It's on New York St just east of College Ave, so about 7 blocks from downtown. It's a tavern but everyone goes for the food. Really good tenderloin skewers, an excellent cheesey potato soup and good sandwiches. The homemade desserts are terrific. I first had the coconut cream pie thinking it would be just ok, since it's not my favorite. It's now top of the list. I have ordered full pies for serving at home.
Also look up Working Man's Friend which is near downtown for good lunch counter burger food. It's at 234 N Belmont. Go west on Washington a little past White River.